高校人才网—国内访问量、信息量领先新金沙高层次人才需求信息平台。
当前位置:高校人才网>高校招聘>高校教师>

Postdoc Positions available in the Organoid Models of Regeneration and Disease Lab at the iHuman Institute, ShanghaiTech University(2019.08)

  • 发布时间:2019-08-13
  • 截止日期:详见正文
  • 所属省份上海
  • 工作地点上海
  • 栏目分类上海高校
  • 招聘人数:2名
  • 报名方式:电子邮件
  • 需求学科(供参考)生物学

The newly launched ‘Organoid Models of Regeneration and Disease’ lab at iHuman Institute, ShanghaiTech University is actively seeking highly motivated, successful, and creative Postdoc(s) with a background in molecular/cancer biology.

 

About the Organoid Models of Regeneration and Disease Lab

The Leushacke lab studies the molecular mechanisms of tissue regeneration and disease of various organs. Our experimental strategy involves the combined use of: (1) in vivo animal models and (2) in vitro mouse and human organoid models that recapitulate key aspects of mouse and human development, adult tissue homeostasis, regeneration and disease.

The lab’s overarching aim is to understand how stem cells, which play instrumental roles during organogenesis, adult homeostasis, are regulated at the molecular level. During embryonic development, members of the WNT family of secreted signaling molecules induce transcriptional programs that control cell proliferation, cell survival, cell fate determination, and tissue patterning. In adults, the WNT pathway governs stem cell niches in several organs, including the intestine and stomach, ensuring tissue homeostasis. Deregulation of the WNT pathway contributes to developmental defects as well as to the initiation and progression of human diseases including several types of cancer.

 

Applicants should refer to the following publications

 

1. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.

Szenker-Ravi E*, Altunoglu U*, Leushacke M*, et al., Nature. 2018 May;557(7706):564-569. doi: 10.1038/s41586-018-0118-y. Epub 2018 May 16.

( * joint first authors)

 

2. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.

de Lau W, Peng WC, Gros P, Clevers H.

Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113.

 

3. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W, et al., Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337.

 

4. Lgr5-Expressing Chief Cells Drive Epithelial Regeneration and Cancer in the Oxyntic Stomach.

Leushacke M, et al., Nat Cell Biol. 2017 Jun 5. doi: 10.1038/ncb3541.

 

5. Ex vivo culture of the intestinal epithelium: strategies and applications.

Leushacke M, et al., Gut. 2014 Aug;63(8):1345-54. doi: 10.1136/gutjnl-2014-307204.

岗位名称: 博士后

岗位人数:2

The successful candidate will pursue innovative biomedical research that exploit transgenic mouse lines and ex vivo organoid culture models aimed at identifying novel WNT-related signaling pathways during embryonic development, in stem cell niches that underpin tissue homeostasis and during cancer initiation and progression.

Candidates should be self-motivated and with a track record of high impact publications. A strong background in cell, molecular and cancer biology is desired. Priority will be given to candidates with demonstrated experience in mouse and organoid biology.

工作条件与工资待遇

按照上海科技大学相关规定执行,根据个人具体情况,提供具有竞争力新金沙薪酬、津贴和福利。

应聘方式

 

Submit a letter outlining your research interest, a CV and the names and addresses of three individuals who can serve as references to the mail addresses given below: [email protected].

更多最新博士后招收资讯请关注高才博士后微信公众号(微信号:bshjob

来源:

http://jobs.shanghaitech.edu.cn/_s57/_t119/00/00/c4206a0/page.psp?_p=YXM9NTcmcD0xJm09TiY_&keyword=Postdoc%20Positions%20available%20in%20the%20Organoid%20Models%20of%20Regeneration%20and%20Disease%20Lab%20at%20the%20iHuman%20Institute,%20ShanghaiTech%20University

 

 

查看次数:

更多资讯!欢迎扫描下方二维码关注高校人才网官方微信(微信号:Gaoxiaojob)。

重要风险提示:如招聘单位在招聘过程中向求职者提出收取押金、保证金、体检费、材料费、成本费,或指定医院体检等,求职者有权要求招聘单位出具物价部门批准新金沙收费许可证明材料,若无法提供相关证明,请求职者提高警惕,有可能属于诈骗或违规行为。
推荐信息
热点信息